"Studies have detailed what demographic in the US displays the highest rate of kratom consumption. These studies have shown that use is highest among White, middle-class men living in suburban areas. Additionally, individuals who have a history of opioid misuse are also more likely to take kratom [18]. Another risk factor for kratom use that has been found is the use of e-cigarettes. A study found that individuals who reported using e-cigarettes within the past year had 4.8 higher odds of using kratom within that same interval than those who did not [19]. This is important to note as the use of e-cigarettes has skyrocketed in recent years, especially among teenagers and young adults [20].
"Kratom is used by many different people in the US for numerous other reasons. Some of the most often cited reasons include to treat chronic pain conditions, depression, and anxiety. Individuals who used kratom for these reasons consumed kratom daily at a typical dose of 1-3 grams, with the kratom converted into a powder so that it could be consumed in a capsule [21]. Kratom may also be used by people due to its stimulant-like effects, causing increased feelings of motivation, higher levels of energy, a stronger desire to work, and an overall increase in productivity [22]. Additionally, there have been reports of kratom being used to treat opioid withdrawal symptoms, as kratom can bind to some of the same receptors as opioids [14,23]."
Kruegel AC, Uprety R, Grinnell SG, et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Cent Sci. 2019;5(6):992-1001. doi:10.1021/acscentsci.9b00141