Kratom

"Kratom (Mitragyna speciosa) is a tropical evergreen tree from the Rubiaceae family, native to Southeast Asia, and its leaves have been used as herbal remedies since at least the mid-19th century [6]. The bioactive alkaloids in kratom may have favorable interactions with neurotransmitter receptors in the central nervous system (D2 dopamine, 5-hydroxytryptamine 2A {HT2A}, and 5-HT2C receptors), which could confer potential benefits for anxiety and other mental health conditions [7,8]. Mitragynine stands as the primary alkaloid in kratom leaves, metabolized to form the active metabolite 7-hydroxymitragynine. A cross-sectional study compared hematology and clinical chemistry parameters between regular kratom users (daily dosages ranging from 76.3 to 114.8 mg of mitragynine) and healthy nonuser controls, demonstrating no significant differences [9]."