Physical and Behavioral Effects of Trenbolone

"Outside of animal or clinical use, trenbolone has three times the androgen receptor binding affinity of testosterone (Yarrow et al., 2011) and thus is renowned for its ability to rapidly increase lean muscle mass while minimising fat accumulation or promoting fat loss. Nevertheless, these benefits are accompanied by significant risk. Trenbolone is associated with cardiovascular complications (Aknouche et al., 2021). Short-term side effects include insomnia, high blood pressure, and increased libido (Aknouche et al., 2021; Piatkowski et al., 2023b). Furthermore, trenbolone exposure in brain cell cultures has been found to lead to significant cell damage, resulting in cell death (Zelleroth et al., 2019). Trenbolone's toxicity was reduced when cells were treated with a drug that blocks the androgen receptor which suggests that trenbolone's harmful effects are largely due to its interaction with this receptor (Zelleroth et al., 2019). The psychosocial effects of the drug are also evident (Aknouche et al., 2021; Piatkowski et al., 2023b, 2024; Underwood, 2022) with studies reporting relationship issues, impulsivity, and violent behaviour. Research indicates that people who use trenbolone experience a decline in patience. They also attribute trenbolone to being responsible for relationship breakdowns due to uncharacteristic behaviour ("tren-me"), an effect observed and reported by AAS-using peers who do not use Trenbolone (Lamb et al., 2024; Piatkowski et al., 2023b). Drawing the evidence together, trenbolone has been recognised as disproportionately related to AAS harms and requires further exploration regarding its risk profile."