"Importantly, trenbolone was discussed as having the most deleterious consequences for users which fits with extant work [7]. The data suggests a number of psychosocial harms arising for trenbolone users including the increased social vigilance required which may lead to social difficulties. Specifically, participants reported a decline in patience and attributed trenbolone to being responsible. If they did not ‘filter’, trenbolone users expressed the potential for breakdown in their relationships being directly related to uncharacteristic behaviour (‘tren-me’). Those who had personally used trenbolone reported an extreme shift in risk profile for psychological harms, with users reporting increased aggression and violent behaviour, as well as other emotional and impulsivity regulation issues, fitting with recent work with trenbolone users [7]. Those who did not use trenbolone also reported the readily observable effect of trenbolone on their peers, leading them to behave uncharacteristically. AAS users should be cognisant of the potential for significant harms that may result if they add trenbolone to their regime, while health-care providers working with this group may consider screening specifically for this AAS when working with this client group. These findings are important within the context of ongoing development for harm reduction frameworks for those using AAS both in Australia and internationally.

"Participants understood the potential adverse effects arising from their use of AAS but persisted using regardless and this may be due to the reinforcing properties of AAS. AAS may have reinforcing psychoactive effects including increased self-confidence and aggressiveness, even though they are not generally considered intoxicating substances [33]. For men, the androgenic effects of exogenous AAS may cause suppression of the hypothalamic–pituitary–gonadal axis and sometimes translates into AAS withdrawal syndrome [34] which may cause individuals to be prone to effects of dysphoria and, thus, increase the likelihood of resuming AAS use. However, the present sample did have a number of female users, one of whom reported multiple instances of trenbolone use. Therefore, the mixed gender cohort for this study may be explained through other theoretical frameworks. For example, research has also demonstrated AAS may also have direct rewarding properties, mediated directly via the effects on their metabolites on plasma membranes [35]. Therefore, we propose our data more likely substantiates this hedonic pathway, given that the cohort was mixed and also expressed similar views in their discussions around AAS."


Piatkowski TM, Neumann DL, Dunn M. 'My mind pretty much went to mush': A qualitative exploration of trenbolone in the performance and image enhancing drug community. Drug Alcohol Rev. 2023;42(6):1566-1576. doi:10.1111/dar.13656