"Our results, along with those from a recent study,48 suggest that adults with MDE [Major Depressive Episode] may be particularly vulnerable to cannabis use as beliefs in its therapeutic potential become more widespread and products become more accessible. Moreover, even after adjusting for depression, CUD, cannabis use status, and other potential confounding factors, we found that from 2008 to 2019 among adults aged 18 to 34 years, the adjusted prevalence of suicidal ideation increased 1.4-fold; suicide plan, 1.6-fold; and suicide attempt, 1.4-fold. Furthermore, even for those with neither MDE nor cannabis use, we found upward trends in suicidal ideation and plan among both men and women and in suicide attempt among men. Our results indicate that depression and cannabis use are associated with suicidality but do not appear to be the only causes for the upward trends in suicide among young adults."


Han B, Compton WM, Einstein EB, Volkow ND. Associations of Suicidality Trends With Cannabis Use as a Function of Sex and Depression Status. JAMA Netw Open. 2021;4(6):e2113025. doi:10.1001/jamanetworkopen.2021.13025.