Suicidality Trends, Depression, and Cannabis Use

"Assessing both CUD [Cannabis Use Disorder] and cannabis use status and their associations with suicidal ideation, plan, and attempt, we found that suicidality trends varied by sex, depression, and both CUD and cannabis use status. Our results suggest that CUD, daily cannabis use, and even nondaily cannabis use were associated with a higher prevalence of suicidal ideation, plan, and attempt more significantly in women than in men. Specifically, the adjusted prevalence of past-year suicidal ideation was higher among women with CUD regardless of MDE [Major Depressive Episode] status and among women without MDE but with daily or nondaily cannabis use compared with their male counterparts. We found upward trends in suicidal ideation among women (rather than men) with MDE and CUD or daily and nondaily cannabis use. Compared with their male counterparts, the adjusted prevalence of suicide plan and attempt were higher among women with MDE and CUD or daily cannabis use and among women without MDE but with CUD or daily and nondaily cannabis use. Similarly, from 2008 to 2019, we found an upward trend in suicide plan among women (rather than men) with MDE and daily cannabis use and an upward trend in suicide attempt among women (rather than men) with MDE and CUD. By contrast, among individuals with neither MDE nor cannabis use, the adjusted prevalence of suicidal ideation, plan, and attempt were similar between men and women, and the adjusted prevalence of suicidal ideation was lower among women with MDE without CUD or cannabis use compared with their male counterparts."