"A 2014 meta-analysis of 75 studies concluded that OPCs have largely fulfilled their initial objectives;39 the implementation of new OPCs in places with high rates of IDU and its associated harms appears to be supported by the existing evidence.39 Methodological caveats notwithstanding, drug use supervision and overdose management have the potential to provide health benefits to at-risk PWID as well as economic advantages to the larger community. The preponderance of the evidence suggests these sites are able to provide sterile equipment, overdose reversal, and linkage to medical care for addiction, in the virtual absence of significant direct risks like increases in drug use, drug sales, or crime. OPCs may represent a novel way of addressing some of the many challenges presented by the overdose crisis, and they could contribute to reduced morbidity and mortality, and improved public health.
"Based on the above considerations, there is a clear need for more rigorous research and evaluation of OPCs. Given the amount and quality of the existing data, it may be prudent to consider the American Medical Association’s recommendation of developing and implementing OPC pilot programs in the United States designed, monitored, and evaluated to generate locality-relevant data to inform policymakers on the feasibility and effectiveness of OPCs in reducing harms and health care costs related to IDU.94
National Institutes of Health. Report to Congress: Overdose Prevention Centers. Washington, DC: Dept. of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse. Nov. 2021.