"In 2019, 70,630 deaths from the toxic effects of drug poisoning (drug overdose) occurred in the United States (1), a 4.8% increase compared with 2018 and the highest recorded number in recent history."
Source
Miniño AM, Hedegaard H. Drug poisoning mortality, by state and by race and ethnicity: United States, 2019. NCHS Health E-Stats. Centers for Disease Control, National Center for Health Statistics, 2021.