Drug Use Disorder and Comorbidity / Co-Occurring Conditions

"Drug use disorder was highly associated with alcohol and nicotine use disorders, with ORs (95% CIs) ranging from 2.5 (2.00–3.06) to 4.4 (3.80–5.19) across time frames and severity levels (Table 3). Twelve-month DUD was also positively associated with major depressive disorder, bipolar I, posttraumatic stress disorder, and antisocial PD (any and moderate to severe); dysthymia (any and mild); and borderline and schizotypal PDs across severity levels. Lifetime DUD was associated with major depressive disorder and generalized anxiety disorder (any and mild); bipolar I, dysthymia, posttraumatic stress disorder, and borderline and schizotypal PDs (except mild); and panic disorder, social phobia, and antisocial PD across severity levels."