According to the National Survey on Drug Use and Health, in the United States in 2023 among people aged 12 and older there were an estimated 22,276,000 lifetime users of MDMA, 2,153,000 past-year users, and 471,000 past-month users.
Source
Center for Behavioral Health Statistics and Quality. (2024). Results from the 2023 National Survey on Drug Use and Health: Detailed tables. Rockville, MD: Substance Abuse and Mental Health Services Administration.