Impairment with Alcohol In Combination With Antidepressants

"Antidepressants include selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclics, and tetracyclics. Antidepressants, most commonly in the form of SSRIs, such as fluoxetine (Prozac) and sertraline (Zoloft), can cause impairment, especially if present in high concentrations or if they are taken outside of medical need or therapeutic treatment. There is also an additional risk of impairment associated with combined use with alcohol (Kelly, Darke, & Ross, 2004). Tricyclic and tetracyclic antidepressants can cause drowsiness or sedation, and can impair psychomotor abilities. The sedating effect of antidepressants is greatest when beginning treatment or when the dose is increased (Ramaekers, 2003)."


Kelley-Baker, T., Berning, A., Ramirez, A., Lacey, J. H., Carr, K., Waehrer, G., Compton, R. (2017, May). 2013-2014 National Roadside Study of alcohol and drug use by drivers: Drug results (Report No. DOT HS 812 411). Washington, DC: National Highway Traffic Safety Administration.