"The present study investigated treatment response and retention by gender in North America’s first randomized controlled trial of injectable diacetylmorphine [DAM]. DAM showed greater effectiveness than MMT with respect to treatment retention and response at 12 months for both men and women, although there were significant treatment differences in more sub-scores for men than women. There were no gender differences in overall clinical response and retention at 12 months in the DAM and MMT groups."


Oviedo-Joekes, E., Guh, D., Brissette, S., Marchand, K., Marsh, D., Chettiar, J., Nosyk, B., Krausz, M., Anis, A., & Schechter, M. T. (2010). Effectiveness of diacetylmorphine versus methadone for the treatment of opioid dependence in women. Drug and alcohol dependence, 111(1-2), 50–57. doi.org/10.1016/j.drugalcdep.2010.03.016